Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 10 Researches
8.4
USERS' SCORE
Good
Based on 16 Reviews
8.3
Supplement Facts
Serving Size: 2 Tablets
Serving Per Container: 30
Amount Per Serving
%DV
Magnesium (as magnesium citrate)
400 mg
95%
Sodium
10 mg
<1%
Top Medical Research Studies
9
We analyzed how magnesium supplementation affects the biology of rheumatoid arthritis (RA) in mice. By feeding one group a diet rich in magnesium and another a standard diet over 15 days, we examined changes in their tissue responses.
Our findings revealed that increased magnesium intake may alter gene expression linked to oxidative stress and cellular aging, processes that are significant in RA development. This suggests that magnesium could be beneficial for managing RA and potentially other autoimmune disorders by reducing disease severity and joint damage.
Our findings revealed that increased magnesium intake may alter gene expression linked to oxidative stress and cellular aging, processes that are significant in RA development. This suggests that magnesium could be beneficial for managing RA and potentially other autoimmune disorders by reducing disease severity and joint damage.
Read More
9
We investigated how magnesium (Mg) affects the severity of autoimmune lupus in mice. By feeding MRL/lpr female mice a standard or high magnesium diet for nine weeks, we measured impacts on skin lesions and pathogenic autoantibodies.
The results were encouraging: mice on the high magnesium diet showed significant reductions in skin issues and harmful anti-dsDNA antibodies. Plus, their immune systems displayed more regulatory T cells. However, there were no notable differences in other measured health indicators.
Overall, magnesium supplementation may be a cost-effective and safe complementary treatment for lupus.
The results were encouraging: mice on the high magnesium diet showed significant reductions in skin issues and harmful anti-dsDNA antibodies. Plus, their immune systems displayed more regulatory T cells. However, there were no notable differences in other measured health indicators.
Overall, magnesium supplementation may be a cost-effective and safe complementary treatment for lupus.
Read More
8
Magnesium shows promise for NMOSD
Our investigation focused on how magnesium L-threonate might help those with neuromyelitis optica spectrum disorder (NMOSD).
We examined both mice and cultured human cells to see if long-term magnesium treatment could reduce neuroinflammation, demyelination, and strengthen the blood-brain barrier.
The results were promising; magnesium supplementation appeared to alleviate damage linked to NMOSD by improving blood-brain barrier integrity and dampening inflammation.
This suggests magnesium could be a novel approach to treating NMOSD.
We examined both mice and cultured human cells to see if long-term magnesium treatment could reduce neuroinflammation, demyelination, and strengthen the blood-brain barrier.
The results were promising; magnesium supplementation appeared to alleviate damage linked to NMOSD by improving blood-brain barrier integrity and dampening inflammation.
This suggests magnesium could be a novel approach to treating NMOSD.
Read More
Most Useful Reviews
9
Restored sleep
30 people found this helpful
The effect is clear! On the third day of use, I managed to sleep through the night without waking – something that hadn’t happened for ages. My sleep has restored, and I'm no longer anxious over trivial matters. I don’t think I can do without this magnesium; I’ll continue ordering it.
Read More
9
Vital mineral highlighted
5 people found this helpful
Magnesium is necessary for our bodies. I learned its benefits from a German doctor. Since taking this magnesium, I've begun sleeping well, and I believe it’s the reason. My family has had no complaints about Solgar products. Magnesium should be taken throughout life, especially these days when our food sources are depleted of nutrients.
Read More
9
Nervous system support
2 people found this helpful
Magnesium helps with my nervous system! It addresses microstress and enhances overall calmness, aiding through emotional challenges. I find it improves my sleep and keeps everything functioning well. Solgar is a reputable brand, so I confidently recommend this magnesium to others.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 10 Researches
8.4
- All Researches
9
We analyzed how magnesium supplementation affects the biology of rheumatoid arthritis (RA) in mice. By feeding one group a diet rich in magnesium and another a standard diet over 15 days, we examined changes in their tissue responses.
Our findings revealed that increased magnesium intake may alter gene expression linked to oxidative stress and cellular aging, processes that are significant in RA development. This suggests that magnesium could be beneficial for managing RA and potentially other autoimmune disorders by reducing disease severity and joint damage.
Our findings revealed that increased magnesium intake may alter gene expression linked to oxidative stress and cellular aging, processes that are significant in RA development. This suggests that magnesium could be beneficial for managing RA and potentially other autoimmune disorders by reducing disease severity and joint damage.
Read More
9
We investigated how magnesium (Mg) affects the severity of autoimmune lupus in mice. By feeding MRL/lpr female mice a standard or high magnesium diet for nine weeks, we measured impacts on skin lesions and pathogenic autoantibodies.
The results were encouraging: mice on the high magnesium diet showed significant reductions in skin issues and harmful anti-dsDNA antibodies. Plus, their immune systems displayed more regulatory T cells. However, there were no notable differences in other measured health indicators.
Overall, magnesium supplementation may be a cost-effective and safe complementary treatment for lupus.
The results were encouraging: mice on the high magnesium diet showed significant reductions in skin issues and harmful anti-dsDNA antibodies. Plus, their immune systems displayed more regulatory T cells. However, there were no notable differences in other measured health indicators.
Overall, magnesium supplementation may be a cost-effective and safe complementary treatment for lupus.
Read More
9
We explored the potential of a new magnesium-aluminum layered double hydroxide combined with nano-ceria in treating rheumatoid arthritis (RA). This innovative therapy targets the unhealthy immune environment and the harmful buildup of hydrogen ions associated with RA. By neutralizing excess acidity, we observed improved immune responses, encouraging the body to heal damaged bones. This approach showed promising results in mice models, indicating it may be a viable future treatment for managing RA effectively.
Read More
9
Magnesium aids arthritis through immunity
We explored the effects of a high magnesium diet on rheumatoid arthritis using two mouse models. Our findings suggest that magnesium can significantly reduce arthritis severity and joint damage, while also promoting immune cell types that help combat inflammation.
Interestingly, these benefits seem to hinge on an immune mediator called IL-10 and changes in the gut microbiome, such as increased beneficial bacteria. While our results are promising, it is important to recognize that the protective effects depend on sufficient levels of IL-10, indicating that the relationship between magnesium and immune regulation is quite intricate.
Interestingly, these benefits seem to hinge on an immune mediator called IL-10 and changes in the gut microbiome, such as increased beneficial bacteria. While our results are promising, it is important to recognize that the protective effects depend on sufficient levels of IL-10, indicating that the relationship between magnesium and immune regulation is quite intricate.
Read More
9
Magnesium mitigates MS-related mood issues
We investigated the impact of nanoparticulate magnesium hydride (MgH) on anxiety and depression in multiple sclerosis (MS), a disease often accompanied by these mood disorders. Our findings indicated that MgH treatment significantly improved anxiety and depression-like behaviors in mice with experimental autoimmune encephalomyelitis (EAE).
Additionally, MgH reduced disease severity and inflammatory damage. The proposed mechanism behind these effects involves modulation of microglial polarization and reduced oxidative stress. Thus, MgH shows promise as a potential treatment for psychiatric issues associated with MS.
Additionally, MgH reduced disease severity and inflammatory damage. The proposed mechanism behind these effects involves modulation of microglial polarization and reduced oxidative stress. Thus, MgH shows promise as a potential treatment for psychiatric issues associated with MS.
Read More
User Reviews
USERS' SCORE
Good
Based on 16 Reviews
8.3
- All Reviews
- Positive Reviews
- Negative Reviews
9
Restored sleep
30 people found this helpful
The effect is clear! On the third day of use, I managed to sleep through the night without waking – something that hadn’t happened for ages. My sleep has restored, and I'm no longer anxious over trivial matters. I don’t think I can do without this magnesium; I’ll continue ordering it.
Read More
9
Vital mineral highlighted
5 people found this helpful
Magnesium is necessary for our bodies. I learned its benefits from a German doctor. Since taking this magnesium, I've begun sleeping well, and I believe it’s the reason. My family has had no complaints about Solgar products. Magnesium should be taken throughout life, especially these days when our food sources are depleted of nutrients.
Read More
9
Nervous system support
2 people found this helpful
Magnesium helps with my nervous system! It addresses microstress and enhances overall calmness, aiding through emotional challenges. I find it improves my sleep and keeps everything functioning well. Solgar is a reputable brand, so I confidently recommend this magnesium to others.
Read More
9
Mental clarity achieved
12 people found this helpful
My first magnesium experience has transformed my life! I've realised I was merely existing before. It has organised my nerves and cleared my mind. Situations that once annoyed me are now seen with clarity, and my irritability has vanished.
Read More
8
Peaceful sleep for dad
12 people found this helpful
I've been using magnesium citrate for some time now. I ordered it for my father, whose joints hurt and who struggled with sleeplessness. After taking this product on a doctor’s recommendation, my dad now sleeps peacefully. I often order it for him and also give it to my mum.
Read More
Frequently Asked Questions
9
Restored sleep
30 people found this helpful
The effect is clear! On the third day of use, I managed to sleep through the night without waking – something that hadn’t happened for ages. My sleep has restored, and I'm no longer anxious over trivial matters. I don’t think I can do without this magnesium; I’ll continue ordering it.
7.5
Effective product
3 people found this helpful
Magnesium works wonders! I’ve been taking it for four days now and can already feel the benefits. If you visit my page and enter the code with your first order, you might discover a pleasant surprise.
9
Calmness achieved
1 people found this helpful
I purchased magnesium citrate on my doctor's advice. After a month, I felt a significant improvement—calmness and balance returned. I've ordered more for both myself and my husband.
7.5
Improved sleep quality
1 people found this helpful
This product has excellent features. The doctor prescribed Magnesium B6, and although I was advised to try this specific drug for its superior composition, I felt that after about 2-3 weeks, I could fall asleep quicker, and I became calmer, responding less to stress. I will order more.
9
Vital mineral highlighted
5 people found this helpful
Magnesium is necessary for our bodies. I learned its benefits from a German doctor. Since taking this magnesium, I've begun sleeping well, and I believe it’s the reason. My family has had no complaints about Solgar products. Magnesium should be taken throughout life, especially these days when our food sources are depleted of nutrients.
9
Mental clarity achieved
12 people found this helpful
My first magnesium experience has transformed my life! I've realised I was merely existing before. It has organised my nerves and cleared my mind. Situations that once annoyed me are now seen with clarity, and my irritability has vanished.
9
Muscle soreness relief
1 people found this helpful
Excellent Magnesium! I ordered it for my son-in-law as he suffered from sore calf muscles. Remarkably, everything subsided by the third day after he began taking it every evening.
0
No noticeable effect
I don’t think it works; I won’t be ordering this again, as I haven’t observed any effect.
7.5
High quality choice
2 people found this helpful
Bestseller! The Solgar brand needs no extra advertisement; it’s one of the finest on iHerb. Having tried various magnesium formulas, I settled on this one, well tolerated even for allergy sufferers. I recommend two tablets for effective calming and good sleep but advise taking them in the afternoon and before bedtime to avoid any issues. Magnesium is vital, especially when zinc is consumed, as deficiency affects absorption—Solgar is a top choice.
9
Magnesium aids arthritis through immunity
We explored the effects of a high magnesium diet on rheumatoid arthritis using two mouse models. Our findings suggest that magnesium can significantly reduce arthritis severity and joint damage, while also promoting immune cell types that help combat inflammation.
Interestingly, these benefits seem to hinge on an immune mediator called IL-10 and changes in the gut microbiome, such as increased beneficial bacteria. While our results are promising, it is important to recognize that the protective effects depend on sufficient levels of IL-10, indicating that the relationship between magnesium and immune regulation is quite intricate.
Interestingly, these benefits seem to hinge on an immune mediator called IL-10 and changes in the gut microbiome, such as increased beneficial bacteria. While our results are promising, it is important to recognize that the protective effects depend on sufficient levels of IL-10, indicating that the relationship between magnesium and immune regulation is quite intricate.
9
We investigated how magnesium (Mg) affects the severity of autoimmune lupus in mice. By feeding MRL/lpr female mice a standard or high magnesium diet for nine weeks, we measured impacts on skin lesions and pathogenic autoantibodies.
The results were encouraging: mice on the high magnesium diet showed significant reductions in skin issues and harmful anti-dsDNA antibodies. Plus, their immune systems displayed more regulatory T cells. However, there were no notable differences in other measured health indicators.
Overall, magnesium supplementation may be a cost-effective and safe complementary treatment for lupus.
The results were encouraging: mice on the high magnesium diet showed significant reductions in skin issues and harmful anti-dsDNA antibodies. Plus, their immune systems displayed more regulatory T cells. However, there were no notable differences in other measured health indicators.
Overall, magnesium supplementation may be a cost-effective and safe complementary treatment for lupus.
8
Magnesium shows promise for NMOSD
Our investigation focused on how magnesium L-threonate might help those with neuromyelitis optica spectrum disorder (NMOSD).
We examined both mice and cultured human cells to see if long-term magnesium treatment could reduce neuroinflammation, demyelination, and strengthen the blood-brain barrier.
The results were promising; magnesium supplementation appeared to alleviate damage linked to NMOSD by improving blood-brain barrier integrity and dampening inflammation.
This suggests magnesium could be a novel approach to treating NMOSD.
We examined both mice and cultured human cells to see if long-term magnesium treatment could reduce neuroinflammation, demyelination, and strengthen the blood-brain barrier.
The results were promising; magnesium supplementation appeared to alleviate damage linked to NMOSD by improving blood-brain barrier integrity and dampening inflammation.
This suggests magnesium could be a novel approach to treating NMOSD.
References
- Toaima DN, Abdel-Maksoud KS, Atef HM, Salah NY. Magnesium, fibrinolysis and clotting interplay among children and adolescents with type 1 diabetes mellitus; potential mediators of diabetic microangiopathy. Nutr Diabetes. 2025;15:13. doi:10.1038/s41387-025-00368-9
- Laragione T, Harris C, Gulko PS. Magnesium Supplementation Modifies Arthritis Synovial and Splenic Transcriptomic Signatures Including Ferroptosis and Cell Senescence Biological Pathways. Nutrients. 2024;16. doi:10.3390/nu16234247
- Fu C, Huang L, Lian C, Yue J, Lin P, et al. Effects of long-term magnesium L-threonate supplementation on neuroinflammation, demyelination and blood-brain barrier integrity in mice with neuromyelitis optica spectrum disorder. Brain Res. 2025;1846:149234. doi:10.1016/j.brainres.2024.149234
- Yan Y, Yao C, Zhang B, Yang Z, Xie J, et al. Olanzapine vs. magnesium valproate vs. lamotrigine in anti-N-methyl-D-aspartic acid receptor encephalitis: a retrospective study. BMC Neurol. 2024;24:331. doi:10.1186/s12883-024-03811-z
- Verlato A, Laragione T, Bin S, Kim RH, Salem F, et al. Revised version with tracked changes oral Magnesium reduces levels of pathogenic autoantibodies and skin disease in murine lupus. BMC Immunol. 2024;25:58. doi:10.1186/s12865-024-00650-y
- Liu H, Zhang K, Xiong L. Dietary magnesium intake and rheumatoid arthritis patients' all-cause mortality: evidence from the NHANES database. J Health Popul Nutr. 2024;43:112. doi:10.1186/s41043-024-00597-1
- Fu H, Guo Y, Fang W, Wang J, Hu P, et al. Anti-Acidification and Immune Regulation by Nano-Ceria-Loaded Mg-Al Layered Double Hydroxide for Rheumatoid Arthritis Therapy. Adv Sci (Weinh). 2024;11:e2307094. doi:10.1002/advs.202307094
- Fang J, Cao T, Liu C, Wang D, Zhang H, et al. Association between magnesium, copper, and potassium intakes with risk of rheumatoid arthritis: a cross-sectional study from National Health and Nutrition Examination Survey (NHANES). BMC Public Health. 2023;23:2085. doi:10.1186/s12889-023-16906-y
- Laragione T, Harris C, Azizgolshani N, Beeton C, Bongers G, et al. Magnesium increases numbers of Foxp3+ Treg cells and reduces arthritis severity and joint damage in an IL-10-dependent manner mediated by the intestinal microbiome. EBioMedicine. 2023;92:104603. doi:10.1016/j.ebiom.2023.104603
- Li Z, Chen K, Shao Q, Lu H, Zhang X, et al. Nanoparticulate MgH ameliorates anxiety/depression-like behaviors in a mouse model of multiple sclerosis by regulating microglial polarization and oxidative stress. J Neuroinflammation. 2023;20:16. doi:10.1186/s12974-023-02696-y
